Potassium Carbonate → HCID 69708186, compound

HRID 430607Notes

Reaction equation

HRID 430607 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[C:2]1[CH2:10][CH2:11][CH2:12]Br.[O:14]1[C:18]2([CH2:23][CH2:22][NH:21][CH2:20][CH2:19]2)[O:17][CH2:16][CH2:15]1.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[C:2]1[CH2:10][CH2:11][CH2:12][N:21]1[CH2:22][CH2:23][C:18]2([O:17][CH2:16][CH2:15][O:14]2)[CH2:19][CH2:20]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 674351,4-Dioxa-8-azaspiro(4.5)decaneHCID 18399769HCID 18399769, compound

Product 1

HCID 69708186HCID 69708186, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A solution of 5 g of 3-(benzofuran-2-yl)-1-bromopropane, 3 g of 1, 4-dioxa-8-azaspiro[4.5]decane and 5.8 g of potassium carbonate in 200 ml of acetone is refluxed for 24 hours, and then evaporated to dryness. The residue is taken up in ethyl acetate, washed with water, dried and evaporated to yield the expected product.

Workup

  1. customevaporated to dryness
  2. washwashed with water
  3. customdried
  4. customevaporated

Sources & evidence

ORD record
ord-b108c0e9eece43ceaba86f027af2141d
Source dataset
uspto-grants-2001_11
Patent number
US06323217B2

Reaction notes

Loading…