4-(N-Boc-amino)piperidine → HCID 70198275, compound

HRID 430613Notes

Reaction equation

HRID 430613 reaction equation
[O:1]1[CH2:3][CH:2]1[CH2:4][C:5]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[O:7][CH:6]=1.[NH:14]1[CH2:19][CH2:18][CH:17]([NH:20][C:21](=[O:27])[O:22][C:23]([CH3:26])([CH3:25])[CH3:24])[CH2:16][CH2:15]1>C(O)(C)C>[O:7]1[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[C:5]([CH2:4][CH:2]([OH:1])[CH2:3][N:14]2[CH2:15][CH2:16][CH:17]([NH:20][C:21](=[O:27])[O:22][C:23]([CH3:25])([CH3:24])[CH3:26])[CH2:18][CH2:19]2)=[CH:6]1

Participants

4

Reactant 2

HCID 7238334-(N-Boc-amino)piperidineHCID 18351359HCID 18351359, compound

Product 1

HCID 70198275HCID 70198275, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

A solution of 2.9 g of 3-(2-oxiranylmethyl)benzofuran, 4 g of tert-butyl 4-piperidyl-carbamate and 35 ml of isopropanol is heated at 80° C. for 5 hours. After evaporation to dryness, chromatography over silica gel enables the expected product to be isolated.

Workup

  1. customAfter evaporation to dryness, chromatography over silica gel
  2. customto be isolated

Sources & evidence

ORD record
ord-ae51f488d57b42e1bfd672d56ac92dd8
Source dataset
uspto-grants-2001_11
Patent number
US06323217B2

Reaction notes

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