Hydrochloric Acid → HCID 18351344, compound

HRID 430614Notes

Reaction equation

HRID 430614 reaction equation
Cl.[O:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[C:4]([CH2:11][CH:12]([F:28])[CH2:13][N:14]2[CH2:19][CH2:18][CH:17]([NH:20]C(=O)OC(C)(C)C)[CH2:16][CH2:15]2)=[CH:3]1>C(O)C>[O:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[C:4]([CH2:11][CH:12]([F:28])[CH2:13][N:14]2[CH2:19][CH2:18][CH:17]([NH2:20])[CH2:16][CH2:15]2)=[CH:3]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 70200130HCID 70200130, compound

Product 1

HCID 18351344HCID 18351344, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
50 °C

Procedure

A stream of hydrogen chloride gas is circulated through a solution of 3.64 g of the product obtained in Step A in 70 ml of ethanol. After 2 hours' stirring at 50° C., the reaction mixture is concentrated under reduced pressure. The residue is taken up in water and in 20% sodium hydroxide solution, extracted with dichloromethane, dried and then evaporated, enabling the expected product to be isolated.

Workup

  1. concentrationthe reaction mixture is concentrated under reduced pressure
  2. extractionextracted with dichloromethane
  3. customdried
  4. customevaporated
  5. customto be isolated

Sources & evidence

ORD record
ord-52bf3e289b8440fea62b2d5b725942fd
Source dataset
uspto-grants-2001_11
Patent number
US06323217B2

Reaction notes

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