反应详情

Potassium hydroxide (0.42 g) was added to 4-hydroxyindole (1.00 g) in DMF (25 ml), and the solution was stirred at room temperature for 15 minutes. Benzyl bromide (1.00 ml) was added to the solution, and the solution was stirred at room temperature for 1.5 hours. Since the reaction was not completed, benzyl bromide (0.20 ml) was further added and the solution was stirred for 5 hours. After removing the solvent under reduced pressure, water (50 ml) was added to the residue and the resultant was extracted with ether (3×50 ml). The organic layers were washed with saturated brine, and dried over sodium sulfate. After removing solids by filtration, the solvent was removed under reduced pressure and the obtained crude product was purified by silica gel column chromatography to obtain the desired product (1.43 g, yield: 85%).

1. stirringthe solution was stirred at room temperature for 1.5 hours
2. stirringthe solution was stirred for 5 hours
3. customAfter removing the solvent under reduced pressure, water (50 ml)
4. additionwas added to the residue
5. extractionthe resultant was extracted with ether (3×50 ml)
6. washThe organic layers were washed with saturated brine
7. dry with materialdried over sodium sulfate
8. customAfter removing solids
9. filtrationby filtration
10. customthe solvent was removed under reduced pressure
11. customthe obtained crude product
12. customwas purified by silica gel column chromatography