Furfural → HCID 15517769, compound

HRID 431191Notes

Reaction equation

HRID 431191 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([OH:10])=[O:9])[N:6]=1.[C:11]([N+:15]#[C-:16])([CH3:14])([CH3:13])[CH3:12].[CH:17](=O)[C:18]1[O:22][CH:21]=[CH:20][CH:19]=1>Cl(O)(=O)(=O)=O>[C:11]([NH:15][C:16]1[N:6]2[C:2]([S:3][CH:4]=[C:5]2[CH2:7][C:8]([OH:10])=[O:9])=[N:1][C:17]=1[C:18]1[O:22][CH:21]=[CH:20][CH:19]=1)([CH3:14])([CH3:13])[CH3:12]

Participants

5

Reactant 3

HCID 7362FurfuralHCID 23577Tert-Butyl isocyanideHCID 34665(2-Amino-1,3-thiazol-4-yl)acetic acid

Product 1

HCID 15517769HCID 15517769, compound

Reagents, catalysts & solvents 1

HCID 24247Perchloric AcidSolvent

Procedure

Compound 3 was prepared in accordance with the general synthesis instructions from 1.0 ml (0.1 mmol) (2-aminothiazol-4-yl)acetic acid solution (0.1 M, MC), 0.575 ml (0.115 mmol) tert-butylisonitrile solution (0.2 M, MC), 0.500 ml (0.15 mmol) furfural solution (0.3 M, MC) and 10 μl perchloric acid (w=20%) in a substance library.

Sources & evidence

ORD record
ord-8ee2423e446f435d838c39279d0e48b9
Source dataset
uspto-grants-2003_12
Patent number
US06657064B2

Reaction notes

Loading…