4-Pyridinecarboxaldehyde → HCID 9881550, compound

HRID 431195Notes

Reaction equation

HRID 431195 reaction equation
[NH2:1][C:2]1[N:6]=[CH:5][NH:4][N:3]=1.[C:7]([N+:11]#[C-:12])([CH3:10])([CH3:9])[CH3:8].[N:13]1[CH:18]=[CH:17][C:16]([CH:19]=O)=[CH:15][CH:14]=1>Cl(O)(=O)(=O)=O>[C:7]([NH:11][C:12]1[N:3]2[NH:4][CH:5]=[N:6][C:2]2=[N:1][C:19]=1[C:16]1[CH:17]=[CH:18][N:13]=[CH:14][CH:15]=1)([CH3:10])([CH3:9])[CH3:8]

Participants

5

Reactant 3

HCID 133894-PyridinecarboxaldehydeHCID 23577Tert-Butyl isocyanideHCID 178418311HCID 178418311, compound

Product 1

HCID 9881550HCID 9881550, compound

Reagents, catalysts & solvents 1

HCID 24247Perchloric AcidSolvent

Procedure

Compound 7 was prepared in accordance with the general synthesis instructions from 1.0 ml (0.1 mmol) 3-amino-1,2,4-triazole solution (0.1 M, MC), 0.575 ml (0.115 mmol) tert-butylisonitrile solution (0.2 M, MC), 0.500 ml (0.15 mmol) 4-pyridinecarbaldehyde solution (0.3 M, MC) and 10 μl perchloric acid (w=20%) in a substance library.

Sources & evidence

ORD record
ord-421566932c9b460588e35a05027c6f89
Source dataset
uspto-grants-2003_12
Patent number
US06657064B2

Reaction notes

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