2-Aminothiazole → HCID 22335553, compound

HRID 431211Notes

Reaction equation

HRID 431211 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[CH:5][N:6]=1.[C:7]([N+:11]#[C-:12])([CH3:10])([CH3:9])[CH3:8].[Cl:13][C:14]1[CH:21]=[C:20]([Cl:22])[CH:19]=[CH:18][C:15]=1[CH:16]=O>Cl(O)(=O)(=O)=O>[C:7]([NH:11][C:12]1[N:6]2[C:2]([S:3][CH:4]=[CH:5]2)=[N:1][C:16]=1[C:15]1[CH:18]=[CH:19][C:20]([Cl:22])=[CH:21][C:14]=1[Cl:13])([CH3:10])([CH3:9])[CH3:8]

Participants

5

Reactant 3

HCID 21552-AminothiazoleHCID 134042,4-DichlorobenzaldehydeHCID 23577Tert-Butyl isocyanide

Product 1

HCID 22335553HCID 22335553, compound

Reagents, catalysts & solvents 1

HCID 24247Perchloric AcidSolvent

Procedure

Compound 30 was prepared in accordance with the general synthesis instructions from 1.0 ml (0.1 mmol) 2-amino thiazole solution (0.1 M, MC), 0.575 ml (0.115 mmol) tert-butylisonitrile solution (0.2 M, MC), 0.500 ml (0.15 mmol) 2,4-dichlorobenzaldehyde solution (0.3 M, MC) and 10 μl perchloric acid (w=20%) in a substance library.

Sources & evidence

ORD record
ord-467e015c60f4400c954af1f989b425b8
Source dataset
uspto-grants-2003_12
Patent number
US06657064B2

Reaction notes

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