2-Methoxybenzaldehyde → HCID 22335560, compound

HRID 431214Notes

Reaction equation

HRID 431214 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([OH:10])=[O:9])[N:6]=1.[C:11]([N+:15]#[C-:16])([CH3:14])([CH3:13])[CH3:12].[CH3:17][O:18][C:19]1[CH:26]=[CH:25][CH:24]=[CH:23][C:20]=1[CH:21]=O>Cl(O)(=O)(=O)=O>[C:11]([NH:15][C:16]1[N:6]2[C:2]([S:3][CH:4]=[C:5]2[CH2:7][C:8]([OH:10])=[O:9])=[N:1][C:21]=1[C:20]1[CH:23]=[CH:24][CH:25]=[CH:26][C:19]=1[O:18][CH3:17])([CH3:14])([CH3:13])[CH3:12]

Participants

5

Reactant 3

HCID 86582-MethoxybenzaldehydeHCID 23577Tert-Butyl isocyanideHCID 34665(2-Amino-1,3-thiazol-4-yl)acetic acid

Product 1

HCID 22335560HCID 22335560, compound

Reagents, catalysts & solvents 1

HCID 24247Perchloric AcidSolvent

Procedure

Compound 33 was prepared in accordance with the general synthesis instructions from 1.0 ml (0.1 mmol) (2-aminothiazol-4-yl)acetic acid solution (0.1 M, MC), 0.575 ml (0.115 mmol) tert-butylisonitrile solution (0.2 M, MC), 0.500 ml (0.15 mmol) 2-methoxybenzaldehyde solution (0.3 M, MC) and 10 μl perchloric acid (w=20%) in a substance library.

Sources & evidence

ORD record
ord-894e29847bb047a59cc85a88db1c88fd
Source dataset
uspto-grants-2003_12
Patent number
US06657064B2

Reaction notes

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