2-Aminothiazole → HCID 22335572, compound

HRID 431231Notes

Reaction equation

HRID 431231 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[CH:5][N:6]=1.[C:7]([N+:11]#[C-:12])([CH3:10])([CH3:9])[CH3:8].[CH3:13][C:14]1[CH:21]=[CH:20][C:17]([CH:18]=O)=[CH:16][CH:15]=1.[C:22](Cl)(=[O:24])[CH3:23]>Cl(O)(=O)(=O)=O>[C:7]([N:11]([C:12]1[N:6]2[C:2]([S:3][CH:4]=[CH:5]2)=[N:1][C:18]=1[C:17]1[CH:20]=[CH:21][C:14]([CH3:13])=[CH:15][CH:16]=1)[C:22](=[O:24])[CH3:23])([CH3:10])([CH3:9])[CH3:8]

Participants

6

Reactant 4

HCID 21552-AminothiazoleHCID 6367Acetyl chlorideHCID 77254-MethylbenzaldehydeHCID 23577Tert-Butyl isocyanide

Product 1

HCID 22335572HCID 22335572, compound

Reagents, catalysts & solvents 1

HCID 24247Perchloric AcidSolvent

Procedure

Compound 52 was prepared in accordance with the general synthesis instructions from 1.0 ml (0.1 mmol) 2-amino thiazole solution (0.1 M, MC), 0.575 ml (0.115 mmol) tert-butylisonitrile solution (0.2 M, MC), 0.500 ml (0.15 mmol) 4-methylbenzaldehyde solution (0.3 M, MC) and 10 μl perchloric acid (w=20%) and by reaction with acetyl chloride, the excess acetyl chloride being removed in vacuo.

Workup

  1. customthe excess acetyl chloride being removed in vacuo

Sources & evidence

ORD record
ord-5ff77dde9db943749ccbc57841d9e731
Source dataset
uspto-grants-2003_12
Patent number
US06657064B2

Reaction notes

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