2,3-Dimethoxybenzoic acid → 2,3-Dimethoxybenzoyl chloride

HRID 431890Notes

Reaction equation

HRID 431890 reaction equation
[CH3:1][O:2][C:3]1[C:11]([O:12][CH3:13])=[CH:10][CH:9]=[CH:8][C:4]=1[C:5](O)=[O:6].C(Cl)(=O)C([Cl:17])=O>CN(C)C=O>[CH3:1][O:2][C:3]1[C:11]([O:12][CH3:13])=[CH:10][CH:9]=[CH:8][C:4]=1[C:5]([Cl:17])=[O:6]

Participants

4

Reactant 2

HCID 152042,3-Dimethoxybenzoic acidHCID 65578Oxalyl chloride

Product 1

HCID 27583922,3-Dimethoxybenzoyl chloride

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

2,3-Dimethoxybenzoic acid (182 mg, 1 mmol) was treated with a solution of oxalyl chloride (1.5 mL of 2 M in dichloromethane, 3 mmol) and a catalytic amount of N,N-dimethylformamide. The reaction was stirred at ambient temperature for 2 hours. The excess oxalyl chloride was removed in vacuo to afford 2,3-dimethoxybenzoyl chloride.

Workup

  1. customThe excess oxalyl chloride was removed in vacuo

Sources & evidence

ORD record
ord-ff40b0097c8e41968febceb34c050922
Source dataset
uspto-grants-2003_12
Patent number
US06660753B2

Reaction notes

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