反应详情

温度

-78 °C

A solution of 3-methyl-3-phenylbutyric acid (0.508 g, 2.85 mmol) in dichloromethane (10 mL) at −78° C. was treated with oxalyl chloride (3.62, 28.5 mmol) and 1 drop of dimethylformamide. The reaction mixture was stirred at −78° C. for 10 min, and dry ice/acetone bath was removed to stir at room temperature over night. Solvent was removed under reduced pressure, and dried under high vacuum. The product was used directly for subsequent reaction without analysis.

1. customdry ice/acetone bath was removed
2. stirringto stir at room temperature over night
3. customSolvent was removed under reduced pressure
4. customdried under high vacuum
5. customThe product was used directly for subsequent reaction without analysis