Pentafluorophenol → HCID 10203873, compound

HRID 432643Notes

Reaction equation

HRID 432643 reaction equation
Cl[C:2]1[N:7]=[N:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[CH:10][CH:9]=2)=[C:4]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH:3]=1.[F:22][C:23]1[C:28]([F:29])=[C:27]([F:30])[C:26]([F:31])=[C:25]([F:32])[C:24]=1[OH:33]>>[CH3:15][O:14][C:11]1[CH:12]=[CH:13][C:8]([C:5]2[N:6]=[N:7][C:2]([O:33][C:24]3[C:25]([F:32])=[C:26]([F:31])[C:27]([F:30])=[C:28]([F:29])[C:23]=3[F:22])=[CH:3][C:4]=2[C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 13041PentafluorophenolHCID 18760041HCID 18760041, compound

Product 1

HCID 10203873HCID 10203873, compound

Procedure

In a similar manner as in Example 2, 6-chloro-3-(4-methoxyphenyl)-4-phenylpyridazine (200 mg, 0.675 mmol) and 2,3,4,5,6-pentafluorophenol were reacted as starting materials at 150° C. for 48 hours and post-treatment was then conducted, whereby the title compound was obtained as a colorless crystalline powder (91.2 mg, 30.5%). Melting point: 133.1-133.9° C. (ethyl acetate-hexane).

Workup

  1. customat 150° C.
  2. customfor 48 hours

Sources & evidence

ORD record
ord-49a67e3429584fc594a642f41da29076
Source dataset
uspto-grants-2003_12
Patent number
US06664256B1

Reaction notes

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