2,4-Difluoroaniline → HCID 18760015, compound

HRID 432652Notes

Reaction equation

HRID 432652 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]=[N:11][C:12](Cl)=[CH:13][C:14]=2[C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=2)=[CH:5][CH:4]=1.[F:24][C:25]1[CH:31]=[C:30]([F:32])[CH:29]=[CH:28][C:26]=1[NH2:27]>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]=[N:11][C:12]([NH:27][C:26]3[CH:28]=[CH:29][C:30]([F:32])=[CH:31][C:25]=3[F:24])=[CH:13][C:14]=2[C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=2)=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 97092,4-DifluoroanilineHCID 125680843,4-Bis(4-methoxyphenyl)-6-chloropyridazine

Product 1

HCID 18760015HCID 18760015, compound

Procedure

In a similar manner as in Example 2, 3,4-bis-(4-methoxyphenyl)-6-chloropyridazine (264.2 mg, 0.809 mmol) and 2,4-difluoroaniline were reacted as starting materials at 100° C. for 12 hours and post-treatment was then conducted, whereby the title compound was obtained as a colorless crystalline powder (328.8 mg, 97.0%). Melting point: 177.4-178.0° C. (chloroform-diethyl ether-hexane).

Workup

  1. customat 100° C.
  2. customfor 12 hours

Sources & evidence

ORD record
ord-50ccb7e1c76b4f61aa977a142031a8e1
Source dataset
uspto-grants-2003_12
Patent number
US06664256B1

Reaction notes

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