反应详情

A stirred mixture of homophthalimide (15 g, 93 mmol), benzaldehyde (9.9 g, 93 mmol), piperidine (9 ml) and acetic acid (465 ml) was heated under reflux for 1 hour, cooled to ambient temperature and diluted with water (500 ml). The resulting solid was collected by filtration, washed with water and dried in vacuo to give 4-benzylidenehomophthalimide (18.5 g, 82%) as a solid; m.pt. 173-177° C. Used crude for the next step.

1. temperaturewas heated
2. temperatureunder reflux for 1 hour
3. filtrationThe resulting solid was collected by filtration
4. washwashed with water
5. customdried in vacuo