反应详情

温度

0 °C

Under a nitrogen atmosphere, POCl3 (16.42 ml, 0.17 mol) was slowly added to a chilled (0° C.) flask containing N,N-dimethylformamide (100 ml). The resulting solution was slowly warmed to room temperature and then added dropwise to a suspension of 4-nitro-tetrazolo[1,5-a]quinolin-5-ol in N,N-dimethylformamide (300 ml). The reaction was heated to 100° C. for 30 minutes. The orange/red solution was quenched by pouring over 1 liter of ice water. A yellow precipitate formed and was collected by filtration, redissolved in chloroform (approx. 750 ml), dried (Na2SO4), filtered, and concentrated in vacuo to yield 33.74 g of 5-chloro-4-nitrotetrazolo[1,5-a]quinoline as a yellow solid.

1. temperatureThe resulting solution was slowly warmed to room temperature
2. temperatureThe reaction was heated to 100° C. for 30 minutes
3. customThe orange/red solution was quenched
4. additionby pouring over 1 liter of ice water
5. customA yellow precipitate formed
6. filtrationwas collected by filtration
7. dissolutionredissolved in chloroform (approx. 750 ml)
8. dry with materialdried (Na2SO4)
9. filtrationfiltered
10. concentrationconcentrated in vacuo