p-Toluenesulfonic acid monohydrate → p-Toluenesulfonic acid

HRID 43273Notes

Reaction equation

HRID 43273 reaction equation
O.[C:2]1([CH3:12])[CH:7]=[CH:6][C:5]([S:8]([OH:11])(=[O:10])=[O:9])=[CH:4][CH:3]=1>CC(C)=O>[CH3:12][C:2]1[CH:7]=[CH:6][C:5]([S:8]([OH:11])(=[O:10])=[O:9])=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 521998p-Toluenesulfonic acid monohydrate

Product 1

HCID 6101p-Toluenesulfonic acidYield 230.1%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

The compound 5 (4.0 g; purity: 96.9%) was dispersed in acetone (120 mL) and then p-toluenesulfonate monohydrate (2.16 g) was added thereto at room temperature. After stirring for 1 hour, the crystals deposited therefrom were filtered and washed with acetone (20 mL) to give 4.5 g (yield: 75%) of p-toluenesulfonate of the compound 5 in 99.1% purity.

Workup

  1. customat room temperature
  2. filtrationthe crystals deposited therefrom were filtered
  3. washwashed with acetone (20 mL)

Sources & evidence

ORD record
ord-42cd47698733458084724c2fe9786be6
Source dataset
uspto-grants-2013_09
Patent number
US08536342B2

Reaction notes

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