反应详情

The reaction was run in the same manner as ethyl 1-benzoyl-3-piperidinecarboxylate, starting with 1-benzoyl-3-piperidinecarbonyl chloride (216.2 mg; 0.86 mmol), diisopropylethylamine (350 μl; 2.0 mmol) and commercially available ethylamine hydrochloride (74.6 mg; 0.86 mmol). The crude product was purified by chromatography on silica, eluting with 100% ethyl acetate, giving N-ethyl 1-benzoyl-3-piperidinecarboxamide (144.3 mg) as a white, sticky, semi-solid. MS m/z (positive ion) 362 (25), 261 (MH+; 100).

1. customThe crude product was purified by chromatography on silica
2. washeluting with 100% ethyl acetate