反应详情

The reaction was run in the same manner as ethyl 1-benzoyl-3-piperidinecarboxylate, starting with 1-(2-thiopheneacetyl)-3-piperidinecarbonyl chloride (609.8 mg; 2.25 mmol), diisopropylethylamine (920 μl; 5.28 mmol) and commercially available ethylamine hydochloride (204.8 mg; 2.51 mmol). The crude product was purified by chromatography on silica, eluting with 100% ethyl acetate, giving N-ethyl 1-(2-thiopheneacetyl)-3-piperidinecarboxamide (437.5 mg) as a thick, brown syrup. MS m/z (positive ion) 303 (M+Na+; 25), 281 (MH+; 100), 157 (25).

1. customThe crude product was purified by chromatography on silica
2. washeluting with 100% ethyl acetate