Chloroform → 1-tert-Butyl-3,3,5,5-tetraethylpiperazin-2-one

HRID 432897Notes

Reaction equation

[CH2:1]([C:3]([NH2:12])([CH2:10][CH3:11])[CH2:4][NH:5][C:6]([CH3:9])([CH3:8])[CH3:7])[CH3:2].[CH2:13]([C:15]([CH2:17][CH3:18])=O)[CH3:14].[OH-:19].[Na+].[CH:21](Cl)(Cl)Cl>>[C:6]([N:5]1[CH2:21][C:15]([CH2:17][CH3:18])([CH2:13][CH3:14])[NH:12][C:3]([CH2:10][CH3:11])([CH2:1][CH3:2])[C:4]1=[O:19])([CH3:7])([CH3:9])[CH3:8]

Participants

Reactant 4

HCID 6212Chloroform

HCID 7288Ethyl ketone

HCID 14798Sodium Hydroxide

HCID 18760498HCID 18760498, compound

Product 1

HCID 221822591-tert-Butyl-3,3,5,5-tetraethylpiperazin-2-oneYield 52%

Procedure

In analogy to Example B21, 1,1-diethyl-2-t-butylaminoethylamin, diethylketon, chloroform and NaOH are reacted to give the title compound (52%) as a yellow oil.

Sources & evidence

ORD record: ord-8d02224f77164396bdabc8ebde216447
Source dataset: uspto-grants-2003_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06664353B2

Reaction notes

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