Hydrochloric Acid → HCID 45094786, compound

HRID 433020Notes

Reaction equation

HRID 433020 reaction equation
[CH2:1]([N:3]1[C:7]2[CH:8]=[C:9]([C:12]([OH:14])=[O:13])[CH:10]=[CH:11][C:6]=2[N:5]=[N:4]1)[CH3:2].Cl.[CH3:16]O>C(=O)(O)[O-].[Na+]>[CH3:16][O:13][C:12]([C:9]1[CH:10]=[CH:11][C:6]2[N:5]=[N:4][N:3]([CH2:1][CH3:2])[C:7]=2[CH:8]=1)=[O:14]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 18760809467235-10-5

Product 1

HCID 45094786HCID 45094786, compound

Reagents, catalysts & solvents 1

HCID 516892Sodium BicarbonateSolvent

Conditions

Temperature
65 °C

Procedure

3-Ethyl-3H-benzotriazole-5-carboxylic acid (0.15 g) was diluted with methanol and treated with HCl (gas). The reaction was then heated to 65° C. for 18 hours. The mixture was allowed to cool to 23° C. and was diluted with saturated sodium bicarbonate and extracted with ethyl acetate. The organic layer was dried with sodium sulfate and concentrated to give 3-ethyl-3H-benzotriazole-5-carboxylic acid methyl ester (0.143 g).

Workup

  1. temperatureto cool to 23° C.
  2. extractionextracted with ethyl acetate
  3. dry with materialThe organic layer was dried with sodium sulfate
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-9c717bd12cae43d9bb32d645a085f0d2
Source dataset
uspto-grants-2003_12
Patent number
US06664395B2

Reaction notes

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