Sodium hydride → HCID 131724045, compound

HRID 433558Notes

Reaction equation

HRID 433558 reaction equation
[N:1]1[C:5]2[CH2:6][CH2:7][CH2:8][CH2:9][C:4]=2[NH:3][CH:2]=1.[H-].[Na+].[Cl:12][CH2:13][C:14]1[N:15]=[CH:16][N:17]([C:19]2[CH:24]=[CH:23][C:22]([Cl:25])=[C:21]([Cl:26])[CH:20]=2)[CH:18]=1>>[ClH:12].[Cl:26][C:21]1[CH:20]=[C:19]([N:17]2[CH:18]=[C:14]([CH2:13][N:1]3[C:5]4[CH2:6][CH2:7][CH2:8][CH2:9][C:4]=4[N:3]=[CH:2]3)[N:15]=[CH:16]2)[CH:24]=[CH:23][C:22]=1[Cl:25]

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 3042634,5,6,7-Tetrahydro-1H-benzimidazoleHCID 234450324-Chloromethyl-1-(3,4-dichloro-phenyl)-1H-imidazole

Product 1

HCID 131724045HCID 131724045, compound

Procedure

Reaction of 4,5,6,7-tetrahydrobenzimidazole with sodium hydride followed by treatment with 4-chloromethyl-1-(3,4-dichloro-phenyl)-1H-imidazole led after extractive workup and chromatography to the free base of the title compound which was converted into its white hydrochloride salt. Mp. >250° C. (MeOH/Et2O), MS: m/e=346 (M+).

Sources & evidence

ORD record
ord-05a4da84369548b2bb4f1c78263eb8ea
Source dataset
uspto-grants-2003_12
Patent number
US06667335B2

Reaction notes

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