m-Chloroperbenzoic acid → HCID 18755929, compound

HRID 433863Notes

Reaction equation

HRID 433863 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[C:9]1[O:10][CH2:11][CH:12]([C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:21]=[CH:22][C:23]([S:26][CH2:27][CH3:28])=[N:24][CH:25]=3)=[CH:16][CH:15]=2)[N:13]=1.ClC1C=CC=C(C(OO)=[O:37])C=1>ClC(Cl)C>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[C:9]1[O:10][CH2:11][CH:12]([C:14]2[CH:15]=[CH:16][C:17]([C:20]3[CH:21]=[CH:22][C:23]([S:26]([CH2:27][CH3:28])=[O:37])=[N:24][CH:25]=3)=[CH:18][CH:19]=2)[N:13]=1

Participants

4

Reactant 2

HCID 70297m-Chloroperbenzoic acidHCID 18755941HCID 18755941, compound

Product 1

HCID 18755929HCID 18755929, compound

Reagents, catalysts & solvents 1

HCID 63651,1-DichloroethaneSolvent

Procedure

2-(2,6-Difluorophenyl)-4-[4-(2-ethylthiopyridin-5-yl)phenyl]oxazoline (Ex. No. 39; 0.60 g, 1.5 mmol) was stirred for 5 hours at 20° C. with 3-chloroperbenzoic acid (0.41 g, 1.7 mmol) in dichloroethane (10 ml). After extraction and chromatography, 2-(2,6-difluorophenyl)-4-[4-(2-ethylsulfinylpyridin-5-yl)phenyl]oxazoline was obtained, 0.21 g, colorless oil.

Workup

  1. extractionAfter extraction and chromatography

Sources & evidence

ORD record
ord-5b6b77bdfd5d4404b80d138dcbba62f4
Source dataset
uspto-grants-2003_12
Patent number
US06670307B2

Reaction notes

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