Isopropanol → HCID 59047204, compound

HRID 434081Notes

Reaction equation

HRID 434081 reaction equation
O[CH:2]1[N:6]([C:7]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[C:10]([C:17]#[N:18])=[CH:9][CH:8]=2)[C:5](=[O:19])[N:4]2[CH2:20][CH2:21][C@H:22]([OH:23])[C@H:3]12.C(O)(C)C>CCCCCC>[OH:23][C@@H:22]1[C@H:3]2[N:4]([C:5](=[O:19])[N:6]([C:7]3[C:16]4[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=4)[C:10]([C:17]#[N:18])=[CH:9][CH:8]=3)[CH2:2]2)[CH2:20][CH2:21]1

Participants

4

Reactant 2

HCID 3776IsopropanolHCID 59047185HCID 59047185, compound

Product 1

HCID 59047204HCID 59047204, compoundYield 24%

Reagents, catalysts & solvents 1

HCID 8058HexaneSolvent

Procedure

The title compound (40 mg) was prepared from compound 42A (176 mg) by procedures analogous to those described in Example 41B. mp 226-228° C. Chiral HPLC: 99% at 7.36 min (retention time) (CHIRALPAK® AD column 4.6×250 mm; 40% isopropanol in hexane over 20 minutes, 1 mL/min, monitoring at 220 nM); MS (ES): m/z 294 [M+1]+.

Sources & evidence

ORD record
ord-67ca871a4f14466e8df1765d78133d79
Source dataset
uspto-grants-2003_12
Patent number
US06670386B2

Reaction notes

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