(Trifluoromethyl)trimethylsilane → HCID 22645731, compound

HRID 434114Notes

Reaction equation

HRID 434114 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[C:7](=[O:11])[C:6]([F:16])([S:12]([CH3:15])(=[O:14])=[O:13])[CH2:5]2.C[Mg]Br.[F:20][C:21]([Si](C)(C)C)([F:23])[F:22].[F-].C([N+](CCCC)(CCCC)CCCC)CCC>O1CCCC1>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[C:7]([C:21]([F:23])([F:22])[F:20])([OH:11])[C:6]([F:16])([S:12]([CH3:15])(=[O:13])=[O:14])[CH2:5]2

Participants

6

Reactant 4

HCID 552549(Trifluoromethyl)trimethylsilaneHCID 2724141Tetrabutylammonium FluorideHCID 9899948HCID 9899948, compoundHCID 178418573HCID 178418573, compound

Product 1

HCID 22645731HCID 22645731, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

If 5-chloro-2-fluoro-2-methanesulfonylindan-1-one is, instead of methylmagnesium bromide, reacted with trifluoromethyltrimethylsilane and tetrabutylammonium fluoride in tetrahydrofuran, 5-chloro-2-fluoro-2-methyanesulfonyl-1-trifluoromethylindan-1-ol of molecular weight 332.7 (C11H9CIF4SO3); MS (ESI): 333.20 (MH+) is obtained.

Workup

  1. customMS (ESI): 333.20 (MH+) is obtained

Sources & evidence

ORD record
ord-bf5b56e6ce6c47a1b43f66cdb3f80ed4
Source dataset
uspto-grants-2003_12
Patent number
US06670401B2

Reaction notes

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