反应详情

(S)-3-Acetyl-4-methyl-2,5-oxazolidinedione (N-acetyl-L-alanine-NCA)(424 mg, 2.7 mmol) was dissolved in ethyl acetate (10 mL), followed by the addition of (S)-1-(p-tolyl)ethylamine (406 mg, 3 mmol) at 0° C. The resulting mixture was stirred for 30 minutes. The reaction mixture was poured into 1 N hydrochloric acid (25 mL), followed by extraction with ethyl acetate (25 mL). The organic layer was washed successively with a saturated aqueous solution of sodium hydrogencarbonate (25 mL) and a saturated aqueous solution of sodium chloride (25 mL), and was then dried over anhydrous magnesium sulfate. The organic layer was concentrated under reduced pressure, and the resulting white solid was washed with hexane-ethyl acetate to afford the title compound (380 mg, 57%) as white crystals.

1. extractionfollowed by extraction with ethyl acetate (25 mL)
2. washThe organic layer was washed successively with a saturated aqueous solution of sodium hydrogencarbonate (25 mL)
3. dry with materiala saturated aqueous solution of sodium chloride (25 mL), and was then dried over anhydrous magnesium sulfate
4. concentrationThe organic layer was concentrated under reduced pressure
5. washthe resulting white solid was washed with hexane-ethyl acetate