反应详情

To a solution of (4-fluoro-phenyl)-piperidin-4-yl-methanone (3.5 g, 17 mmol) in dry tetrahydrofuran (50 ml) is added (R)-4-formyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester (3.9 g, 17 mmol) and sodium triacetoxyborohydride (5.4 g, 25 mmol), and the reaction mixture stirred for 18 hours at ambient temperature. The reaction mixture is filtered and the solvent evaporated to give a white solid. The solid is taken up in dichloromethane (50 ml) and washed with saturated sodium bicarbonate solution (50 ml), water (2×50 ml) and brine (50 ml). The organic phase is dried over magnesium sulphate and evaporated to afford the product, [MH]+420.9.

1. filtrationThe reaction mixture is filtered
2. customthe solvent evaporated
3. customto give a white solid
4. washwashed with saturated sodium bicarbonate solution (50 ml), water (2×50 ml) and brine (50 ml)
5. dry with materialThe organic phase is dried over magnesium sulphate
6. customevaporated
7. customto afford the product, [MH]+420.9