Sodium → HCID 20493842, compound

HRID 434399Notes

Reaction equation

HRID 434399 reaction equation
C([O:9][C:10]1[CH:15]=[CH:14][C:13]([O:16][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[C:12]([S:24]([CH3:26])=O)[CH:11]=1)(=O)C1C=CC=CC=1.[Na]>O.O.O.O.O.O.[Co](Cl)Cl>[CH2:17]([O:16][C:13]1[CH:14]=[CH:15][C:10]([OH:9])=[CH:11][C:12]=1[S:24][CH3:26])[C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1

Participants

4

Reactant 2

HCID 5360545SodiumHCID 54114875HCID 54114875, compound

Product 1

HCID 20493842HCID 20493842, compound

Reagents, catalysts & solvents 1

HCID 517166Dichlorocobalt hexahydrateCatalyst

Procedure

It is contemplated that reacting 4-benzyloxy-3-(methylsulfinyl)phenyl benzoate prepared according to the procedure of Example 3A with cobalt chloride hexahydrate and sodium bobohydride according to the procedure described in Example 1H will give 4-benzyloxy-3-(methylthio)-phenol and that substituting the latter for 4-benzyloxy-3-(methylsulfinyl)phenol in the procedures of Examples 3C and 3D will afford 1-[4-hydroxy-3-(methylthio)phenoxy]-3-[[3-(4-methoxyphenyl)-1-methylpropyl]-amino]-2-propanol (Formula I: Y=CH3S, R1 =H, ##STR16##

Workup

  1. customprepared

Sources & evidence

ORD record
ord-8122d8e680d1484380742daed489e10c
Source dataset
uspto-grants-1983_08
Patent number
US04396629

Reaction notes

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