Propylamine → N-(2,2-Diethoxyethyl)propan-1-amine

HRID 434463Notes

Reaction equation

HRID 434463 reaction equation
[CH2:1]([NH2:4])[CH2:2][CH3:3].[OH-].[Na+].Br[CH2:8][CH:9]([O:13][CH2:14][CH3:15])[O:10][CH2:11][CH3:12]>>[CH2:1]([NH:4][CH2:8][CH:9]([O:13][CH2:14][CH3:15])[O:10][CH2:11][CH3:12])[CH2:2][CH3:3]

Participants

4

Reactant 3

HCID 7852PropylamineHCID 14798Sodium HydroxideHCID 74852Ethane, 2-bromo-1,1-diethoxy-

Product 1

HCID 13175518N-(2,2-Diethoxyethyl)propan-1-amine

Procedure

Propylamine (100 ml) and 1-bromo-2,2-diethoxyethane (50 ml) were charged into a glass reaction flask equipped with a stirrer, thermometer, heater and reflux condenser. The reaction mixture was then heated at reflux for a period of one hour with stirring. After this time the mixture is treated with 50% by weight aqueous sodium hydroxide and was then distilled under reduced pressure to yield the desired product N-propyl-N-(2,2-diethoxyethyl)amine.

Workup

  1. customequipped with a stirrer
  2. temperaturethermometer, heater and reflux condenser
  3. temperatureThe reaction mixture was then heated
  4. temperatureat reflux for a period of one hour
  5. distillationwas then distilled under reduced pressure

Sources & evidence

ORD record
ord-94d586cfe1204397890f20a7399af269
Source dataset
uspto-grants-1983_08
Patent number
US04397677

Reaction notes

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