1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride → tert-Butyl cis(+/-)-4-{[(4-chloro-5-methyl-1H-imidazol-2-yl)carbonyl]amino}-3-propoxypiperidine-1-carboxylate

HRID 43448ノート

反応式

HRID 43448 の反応式
[NH2:1][C@H:2]1[CH2:7][CH2:6][N:5]([C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])[CH2:4][C@H:3]1[O:15][CH2:16][CH2:17][CH3:18].[Cl:19][C:20]1[N:21]=[C:22]([C:26](O)=[O:27])[NH:23][C:24]=1[CH3:25].CCN=C=NCCCN(C)C.Cl>CN(C1C=CN=CC=1)C>[Cl:19][C:20]1[N:21]=[C:22]([C:26]([NH:1][C@H:2]2[CH2:7][CH2:6][N:5]([C:8]([O:10][C:11]([CH3:12])([CH3:13])[CH3:14])=[O:9])[CH2:4][C@H:3]2[O:15][CH2:16][CH2:17][CH3:18])=[O:27])[NH:23][C:24]=1[CH3:25]

参加物

5

反応物 3

HCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 144742774-chloro-5-methyl-1H-imidazole-2-carboxylic acid2 回HCID 67548306Tert-butyl cis(+/-)-4-amino-3-propoxypiperidine-1-carboxylate

生成物 1

HCID 86648468tert-Butyl cis(+/-)-4-{[(4-chloro-5-methyl-1H-imidazol-2-yl)carbonyl]amino}-3-propoxypiperidine-1-carboxylate収率 60%

試薬・触媒・溶媒 1

HCID 142844-(Dimethylamino)pyridine触媒

実験手順

The same operation as in Example (1g) was performed using tert-butyl cis(±)-4-amino-3-propoxypiperidine-1-carboxylate obtained in Example (20a) (0.22 g, 0.85 mmol), 4-chloro-5-methyl-1H-imidazole-2-carboxylic acid obtained by the method described in Example (5c) (0.11 g, 0.64 mmol), WSC hydrochloride (0.63 g, 3.28 mmol) and DMAP (84 mg, 0.69 mmol), to obtain 0.15 g of the title compound as a pale yellow solid (60%).

後処理

  1. customobtained by the method

出典と根拠

ORDレコード
ord-bec2c133dc154395b3cc2cbb68146849
出典データセット
uspto-grants-2013_09
特許番号
US08536197B2

反応ノート

読み込み中…