反应详情

3 g of N-benzo[b]furan-7-yl-N'-2-hydroxyethylthiourea in 12 ml of concentrated hydrochloric acid are heated for 10 minutes on a steam bath. The mixture is treated with 60 ml of water, treated with active charcoal and filtered. The colourless filtrate is made basic with conc. aqueous sodium hydroxide solution. The resultant precipitate is filtered off. After recrystallisation from methanol/ether, the title compound is obtained in free base form. M.Pt. 143°-145°.

1. filtrationfiltered
2. filtrationThe resultant precipitate is filtered off
3. customAfter recrystallisation from methanol/ether