Methane → HCID 13035281, compound

HRID 434557Notes

Reaction equation

HRID 434557 reaction equation
[O:1]1[CH:5]=[CH:4][C:3]2[CH:6]=[CH:7][CH:8]=[C:9]([NH:10][C:11]([NH:13][CH2:14][CH2:15]O)=[S:12])[C:2]1=2.O.C>Cl>[S:12]1[CH2:15][CH2:14][N:13]=[C:11]1[NH:10][C:9]1[C:2]2[O:1][CH:5]=[CH:4][C:3]=2[CH:6]=[CH:7][CH:8]=1

Participants

5

Reactant 3

HCID 297MethaneHCID 962WaterHCID 13035278HCID 13035278, compound

Product 1

HCID 13035281HCID 13035281, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

3 g of N-benzo[b]furan-7-yl-N'-2-hydroxyethylthiourea in 12 ml of concentrated hydrochloric acid are heated for 10 minutes on a steam bath. The mixture is treated with 60 ml of water, treated with active charcoal and filtered. The colourless filtrate is made basic with conc. aqueous sodium hydroxide solution. The resultant precipitate is filtered off. After recrystallisation from methanol/ether, the title compound is obtained in free base form. M.Pt. 143°-145°.

Workup

  1. filtrationfiltered
  2. filtrationThe resultant precipitate is filtered off
  3. customAfter recrystallisation from methanol/ether

Sources & evidence

ORD record
ord-12bfad2e5a224260bead92929086cbdf
Source dataset
uspto-grants-1983_08
Patent number
US04398028

Reaction notes

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