反应详情

温度

55 °C

To a 500 milliliter round bottom flask equipped with a water condenser, magnetic stirrer and drying tube was added 13.72 grams (0.10 mole) of 4-amino-3,5-dimethylphenol, 12.21 grams (0.10 mole) of salicylaldehyde and 250 milliliters of ethyl acetate. The resulting reaction mixture was then heated to 55° C. and stirred for 19 hours at ambient pressure. After cooling the reaction mixture to room temperature, it was filtered and concentrated under reduced pressure to give a brown oil which solidified on standing. The resulting solidified material was slurried in hexane, collected by filtration and dried to yield 19.66 grams (0.082 moles) of 4-(2-hydroxybenzylideneamino)-3,5-dimethylphenol in the form of a yellow solid having a melting point of 145°-147° C.

1. customTo a 500 milliliter round bottom flask equipped with a water condenser, magnetic stirrer
2. customdrying tube
3. customThe resulting reaction mixture
4. temperatureAfter cooling the reaction mixture to room temperature
5. filtrationit was filtered
6. concentrationconcentrated under reduced pressure
7. customto give a brown oil which
8. filtrationcollected by filtration
9. customdried