Tetrahydrofuran → HCID 13092036, compound

HRID 434842Notes

Reaction equation

HRID 434842 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:15][CH3:16])=[C:6]([CH:8]2[O:12][C:11](=[O:13])[NH:10][C:9]2=[O:14])[CH:7]=1.[O:17]1CC[CH2:19][CH2:18]1>C(OC(=O)C)(=O)C>[C:18]([N:10]1[C:9](=[O:14])[CH:8]([C:6]2[CH:7]=[C:2]([Cl:1])[CH:3]=[CH:4][C:5]=2[O:15][CH3:16])[O:12][C:11]1=[O:13])(=[O:17])[CH3:19]

Participants

4

Reactant 2

HCID 8028TetrahydrofuranHCID 13092002HCID 13092002, compound

Product 1

HCID 13092036HCID 13092036, compound

Reagents, catalysts & solvents 1

HCID 7918Acetic AnhydrideCatalyst

Procedure

5-(5-Chloro-2-methoxyphenyl)oxazolidine-2,4-dione (100 mg.) was dissolved in 2.5 ml. of tetrahydrofuran. Excess acetic anhydride (4 drops) was added, and the mixture allowed to stand at room temperature for 16 hours. Evaporation to dryness gave 3-acetyl-5-(5-chloro-2-methoxyphenyl)oxazolidine-2,4-dione [Rf 0.75 (1:1 ethyl acetate: chloroform; m.p. 160°-162° C⟧

Workup

  1. customEvaporation to dryness

Sources & evidence

ORD record
ord-5ae985892c314e77b000380124f9fc3a
Source dataset
uspto-grants-1983_08
Patent number
US04399296

Reaction notes

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