Iodoethane → HCID 20490769, compound

HRID 435071Notes

Reaction equation

HRID 435071 reaction equation
[CH3:1][CH:2]1[CH2:11][CH2:10][C:9]2[C:4](=[CH:5][C:6]([CH3:12])=[CH:7][CH:8]=2)[NH:3]1.C(=O)([O-])[O-].[K+].[K+].I[CH2:20][CH3:21]>O>[CH3:1][CH:2]1[CH2:11][CH2:10][C:9]2[C:4](=[CH:5][C:6]([CH3:12])=[CH:7][CH:8]=2)[N:3]1[CH2:20][CH3:21]

Participants

5

Reactant 3

HCID 6340IodoethaneHCID 11430Potassium CarbonateHCID 20428348Quinoline, 1,2,3,4-tetrahydro-2,7-dimethyl-

Product 1

HCID 20490769HCID 20490769, compoundYield 77.6%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 2,7-dimethyl-1,2,3,4-tetrahydroquinoline (48.3 g. 0.3 m), potassium carbonate (41.4 g, 0.3 m), and iodoethane (100 g) was heated at reflux for 4 hrs. Water (200 ml) was added and then the organic layer was extracted using chloroform (100 ml). The organic layer was separated and dried over sodium sulfate. Chloroform and excess iodoethane were distilled off to leave essentially pure product (44 g), which was used without further purification.

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 4 hrs
  3. extractionthe organic layer was extracted
  4. customThe organic layer was separated
  5. dry with materialdried over sodium sulfate
  6. distillationChloroform and excess iodoethane were distilled off

Sources & evidence

ORD record
ord-b9bc8d12026e47c58c45dfd8acc80a5f
Source dataset
uspto-grants-1983_08
Patent number
US04400318

Reaction notes

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