Hydrazine hydrate (1:1) → HCID 13091051, compound

HRID 435404Notes

Reaction equation

HRID 435404 reaction equation
[NH:1]([C:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30])[C@H:2]([C:12]([NH:14][C@H:15]([C:25](OC)=[O:26])[CH2:16][O:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[O:13])[CH2:3][O:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.O.[NH2:37][NH2:38]>CN(C=O)C>[NH:1]([C:29]([O:31][C:32]([CH3:34])([CH3:35])[CH3:33])=[O:30])[C@H:2]([C:12]([NH:14][C@H:15]([C:25]([NH:37][NH2:38])=[O:26])[CH2:16][O:17][CH2:18][C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1)=[O:13])[CH2:3][O:4][CH2:5][C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 13091049HCID 13091049, compound

Product 1

HCID 13091051HCID 13091051, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The substance [28] (191 g, 0.393 M) was dissolved in DMF (500 ml). Hydrazine hydrate (100%) (200 ml) was added dropwise and stirred at room temperature for three hours. The DMF was removed in vacuo and water was added thereto. The thus-formed precipitate was filtered, dried, and recrystallized twice from ethyl acetate-hexane to obtain the substance [29] (183.6 g, yield: 96.0%).

Workup

  1. customThe DMF was removed in vacuo and water
  2. additionwas added
  3. filtrationThe thus-formed precipitate was filtered
  4. customdried
  5. customrecrystallized twice from ethyl acetate-hexane

Sources & evidence

ORD record
ord-cbed42062156454983277ec165e4cedc
Source dataset
uspto-grants-1983_08
Patent number
US04400316

Reaction notes

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