Hydrochloric Acid → HCID 15619006, compound

HRID 435659Notes

Reaction equation

HRID 435659 reaction equation
[F:1][C:2]([F:20])([F:19])[C:3]1[CH:18]=[CH:17][C:6]2[S:7][C:8]3[CH:16]=[CH:15][CH:14]=[CH:13][C:9]=3[CH:10](O)[CH2:11][C:5]=2[CH:4]=1.[Cl-:21].[Ca+2].[Cl-].Cl>C1C=CC=CC=1>[Cl:21][CH:10]1[C:9]2[CH:13]=[CH:14][CH:15]=[CH:16][C:8]=2[S:7][C:6]2[CH:17]=[CH:18][C:3]([C:2]([F:20])([F:19])[F:1])=[CH:4][C:5]=2[CH2:11]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 5284359Calcium ChlorideHCID 1222397310,11-Dihydro-2-trifluoromethyl-dibenzo[b,f]thiepin-10-ol

Product 1

HCID 15619006HCID 15619006, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

11.4 g of 10,11-dihydro-2-trifluoromethyl-dibenzo[b,f]-thiepin-10-ol 100 ml of benzene and 4 g of calcium chloride are saturated with hydrochloric acid gas for 2 hours at 15° C and subsequently stirred at room temperature for 3 hours. The mixture is filtered and concentrated under reduced pressure. There is obtained 10-chloro-10,11-dihydro-2-trifluoromethyl-dibenzo[b,f]thiepin in the form of yellow crystals.

Workup

  1. filtrationThe mixture is filtered
  2. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-9fc60698191e4701bd673e5a3b62d703
Source dataset
uspto-grants-1977_02
Patent number
US04006145

Reaction notes

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