Hydrochloric Acid → HCID 15606368, compound

HRID 435767Notes

Reaction equation

HRID 435767 reaction equation
[C:1]([NH2:6])(=O)[CH:2]([CH3:4])[CH3:3].[P:7]([OH:10])([OH:9])[OH:8].Cl>>[NH2:6][C:1]([P:7]([OH:10])(=[O:8])[OH:9])([P:7]([OH:10])(=[O:9])[OH:8])[CH:2]([CH3:4])[CH3:3]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 68424IsobutyramideHCID 107909Phosphorous acid

Product 1

HCID 15606368HCID 15606368, compound

Procedure

Into a mixture of 87 gm of isobutyric acid amide and 82 gm of phosphorous acid, hydrogen chloride gas was introduced for 8 hours. During this time the mixture was stirred and the temperature was held at 155° -160° C. By further processing of the reaction mixture analogously to Example 1, the 1-amino-2-methylpropane-1,1 -diphosphonic acid was isolated and purified. The yield was 8 gm.

Workup

  1. additionwas introduced for 8 hours
  2. customwas held at 155° -160° C

Sources & evidence

ORD record
ord-ead04f2ac5ae4d51ab8d778882d63a69
Source dataset
uspto-grants-1977_02
Patent number
US04006182

Reaction notes

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