Benzene → 1-Chloro-5-methoxy-2,6-dimethylheptane

HRID 435781Notes

Reaction equation

HRID 435781 reaction equation
O[CH2:2][CH:3]([CH3:12])[CH2:4][CH2:5][CH:6]([O:10][CH3:11])[CH:7]([CH3:9])[CH3:8].S(Cl)([Cl:15])=O.C1C=CC=CC=1>CN(C)C=O>[Cl:15][CH2:2][CH:3]([CH3:12])[CH2:4][CH2:5][CH:6]([O:10][CH3:11])[CH:7]([CH3:9])[CH3:8]

Participants

5

Reactant 3

HCID 241BenzeneHCID 24386Thionyl ChlorideHCID 213991185-Methoxy-2,6-dimethylheptan-1-ol

Product 1

HCID 213990831-Chloro-5-methoxy-2,6-dimethylheptane

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of 3.4 g. of 1-hydroxy-5-methoxy-2,6-dimethylheptane and 3 g. of thionyl chloride and 60 ml. of dry benzene is treated with 0.2 ml. of dry dimethylformamide and then refluxed for 6 hours. After cooling, the mixture is decanted and 1-chloro-5-methoxy-2,6-dimethylheptane isolated by filtration through silica gel and distillation.

Workup

  1. additionA mixture of 3.4 g
  2. temperatureAfter cooling
  3. customthe mixture is decanted

Sources & evidence

ORD record
ord-7a39b80d0e5a4a259274a3e4984dbe18
Source dataset
uspto-grants-1977_02
Patent number
US04006188

Reaction notes

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