Methane → HCID 20351855, compound

HRID 435841Notes

Reaction equation

HRID 435841 reaction equation
[NH2:1][C:2]1[CH:18]=[CH:17][C:16]([C:19]([O:21][CH2:22][CH3:23])=[O:20])=[CH:15][C:3]=1[CH2:4][N:5](CC1C=CC=CC=1)[CH2:6][CH3:7].[H][H].C.[ClH:27]>CO>[ClH:27].[NH2:1][C:2]1[CH:18]=[CH:17][C:16]([C:19]([O:21][CH2:22][CH3:23])=[O:20])=[CH:15][C:3]=1[CH2:4][NH:5][CH2:6][CH3:7]

Participants

6

Reactant 4

HCID 297MethaneHCID 313Hydrochloric AcidHCID 20351866HCID 20351866, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 20351855HCID 20351855, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

3.8 gm of 2-amino-N-benzyl-5-carbethoxy-N-ethylbenzylamine were hydrogenated in a mixture of 50 ml of methanol and 1 ml of concentrated hydrochloric acid at room temperature and at a hydrogen pressure of 5 atmospheres in the presence of palladized charcoal. Then, the catalyst was filtered off, and the filtrate was evaported to dryness in vacuo. The residue was recrystallized from ethanol by addition of ether, yielding 2-amino-5-carbethoxy-N-ethyl-benzylamine hydrochloride, m.p. 173°-176° C (decomp.).

Workup

  1. filtrationThen, the catalyst was filtered off
  2. customThe residue was recrystallized from ethanol by addition of ether

Sources & evidence

ORD record
ord-13ad504ac29947bebc9e9082483bc303
Source dataset
uspto-grants-1977_02
Patent number
US04006246

Reaction notes

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