Cycloheptylamine → HCID 12671225, compound

HRID 435979Notes

Reaction equation

HRID 435979 reaction equation
Cl[C:2]1[N:7]2[N:8]=[CH:9][N:10]=[C:6]2[N:5]=[C:4]([CH3:11])[C:3]=1[CH2:12][CH2:13]Cl.[CH:15]1([NH2:22])[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1.C(N(CC)CC)C>C(O)C>[CH:15]1([N:22]2[C:2]3[N:7]4[N:8]=[CH:9][N:10]=[C:6]4[N:5]=[C:4]([CH3:11])[C:3]=3[CH2:12][CH2:13]2)[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1

Participants

5

Reactant 3

HCID 2899CycloheptylamineHCID 8471TriethylamineHCID 36386487-chloro-6-(2-chloroethyl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidine

Product 1

HCID 12671225HCID 12671225, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 2g of 7-chloro-6-(2-chloroethyl)-5-methyl-s-triazolo[1,5-a]pyrimidine, 0.98g of cycloheptylamine, 3 ml of triethylamine and 20 ml of ethanol was stirred under reflux for 1.5 hours and treated thereafter as described in Example 5. The crystals thus obtained were crystallized from tetrahydrofuranisopropyl ether to give 1.4g of pale yellow needles of m.p. 197° - 198° C.

Workup

  1. temperatureunder reflux for 1.5 hours
  2. additiontreated
  3. customThe crystals thus obtained
  4. customwere crystallized from tetrahydrofuranisopropyl ether

Sources & evidence

ORD record
ord-fbdc9e5e3c2e41deb9a093e49b0049d8
Source dataset
uspto-grants-1977_02
Patent number
US04007189

Reaction notes

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