Triethylamine → HCID 12671226, compound

HRID 435980Notes

Reaction equation

HRID 435980 reaction equation
Cl[C:2]1[N:7]2[N:8]=[CH:9][N:10]=[C:6]2[N:5]=[C:4]([CH3:11])[C:3]=1[CH2:12][CH2:13]Cl.Cl.[CH:16]1([NH2:24])[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1.C(N(CC)CC)C>C(O)(C)C>[CH:16]1([N:24]2[C:2]3[N:7]4[N:8]=[CH:9][N:10]=[C:6]4[N:5]=[C:4]([CH3:11])[C:3]=3[CH2:12][CH2:13]2)[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 36386487-chloro-6-(2-chloroethyl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidineHCID 214034506332-60-1

Product 1

HCID 12671226HCID 12671226, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

A mixture of 2g of 7-chloro-6-(2-chloroethyl)-5-methyl-s-triazolo[1,5-a]pyrimidine, 1.45g of cyclooctylamine hydrochloride, 4 ml of triethylamine and 20 ml of isopropyl alcohol was stirred under reflux for 1.5 hours, and treated thereafter as described in Example 5. The crystals thus obtained were recrystallized from ethanol to give 1.25g of colorless needles of m.p. 188.5° - 190.5° C.

Workup

  1. temperatureunder reflux for 1.5 hours
  2. additiontreated
  3. customThe crystals thus obtained
  4. customwere recrystallized from ethanol

Sources & evidence

ORD record
ord-6beac1f0b77e4a7e8d2fa2d13ca0352a
Source dataset
uspto-grants-1977_02
Patent number
US04007189

Reaction notes

Loading…