Tert-Butylamine → HCID 21454941, compound

HRID 435983Notes

Reaction equation

HRID 435983 reaction equation
[Cl:1][C:2]1[N:7]2[N:8]=[CH:9][N:10]=[C:6]2[N:5]=[C:4]([CH3:11])[C:3]=1[CH2:12][CH:13](Cl)[CH2:14][CH3:15].[C:17]([NH2:21])([CH3:20])([CH3:19])[CH3:18].C(=O)([O-])[O-:23].[Na+].[Na+]>C(O)C>[OH2:23].[ClH:1].[C:17]([N:21]1[C:2]2[N:7]3[N:8]=[CH:9][N:10]=[C:6]3[N:5]=[C:4]([CH3:11])[C:3]=2[CH2:12][CH:13]1[CH2:14][CH3:15])([CH3:20])([CH3:19])[CH3:18]

Participants

5

Reactant 3

HCID 6385Tert-ButylamineHCID 10340Sodium CarbonateHCID 126712997-Chloro-6-(2-chlorobutyl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidine

Product 1

HCID 21454941HCID 21454941, compoundYield 12.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 2.6g of 7-chloro-6-(2-chlorobutyl)-5-methyl-s-triazolo[1,5-a]pyrimidine, 0.9g of tertbutylamine, 1.8g of sodium carbonate and 20 ml of ethanol was stirred at room temperature for 1 hour and then refluxed for 5 hours. The reaction mixture was thereafter treated by the same manner as described in Example 10. The crystals thus obtained were recrystallized from isopropyl alcohol-isopropyl ether to give 400 mg of pale yellow crystals of m.p. 170° C (decomp).

Workup

  1. temperaturerefluxed for 5 hours
  2. additionThe reaction mixture was thereafter treated by the same manner
  3. customThe crystals thus obtained
  4. customwere recrystallized from isopropyl alcohol-isopropyl ether

Sources & evidence

ORD record
ord-8d00c3ff1bb040fba2afc4135c8f6d56
Source dataset
uspto-grants-1977_02
Patent number
US04007189

Reaction notes

Loading…