Benzyl Bromide → HCID 21454950, compound

HRID 436015Notes

Reaction equation

HRID 436015 reaction equation
[Cl:1][CH:2]1[CH2:7][NH:6][CH:5]([CH:8]2[NH:13][C:12](=[O:14])[CH:11]([CH:15]3[CH2:20][CH2:19][CH:18]([Cl:21])[CH2:17][NH:16]3)[NH:10][C:9]2=[O:22])[CH2:4][CH2:3]1.[CH2:23](Br)[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>CC(C)=O>[CH2:23]([N:6]1[CH2:7][CH:2]([Cl:1])[CH2:3][CH2:4][CH:5]1[CH:8]1[NH:13][C:12](=[O:14])[CH:11]([CH:15]2[CH2:20][CH2:19][CH:18]([Cl:21])[CH2:17][N:16]2[CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[NH:10][C:9]1=[O:22])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1

Participants

4

Reactant 2

HCID 7498Benzyl BromideHCID 1147283,6-Bis(5-chloro-2-piperidyl)-2,5-piperazinedione

Product 1

HCID 21454950HCID 21454950, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

One mole of 3,6-bis(5-chloro-2piperidinyl)-2,5-piperazinedione is stirred in 150 parts of acetone and 2.2 moles of benzyl bromide is added. The mixture is stirred 24 hours and refluxed 24 hours. The solvent is removed in vacuo and treated as in the preparation of 3,6-bis-(1-methyl-5-chloro-2-piperidinyl)-2,5-piperazinedone.

Workup

  1. additionis added
  2. temperaturerefluxed 24 hours
  3. customThe solvent is removed in vacuo
  4. additiontreated as in the preparation of 3,6-bis-(1-methyl-5-chloro-2-piperidinyl)-2,5-piperazinedone

Sources & evidence

ORD record
ord-2b990c78f42043cba73466e3eaceff3c
Source dataset
uspto-grants-1977_02
Patent number
US04007190

Reaction notes

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