Hydrochloric Acid → HCID 12944295, compound

HRID 436158Notes

Reaction equation

HRID 436158 reaction equation
C[N:2]([CH3:5])C=O.Cl[CH:7]1[C:15]2[CH:14]=[CH:13][CH:12]=[C:11]([C:16]([OH:18])=[O:17])[C:10]=2[CH2:9][CH2:8]1.[C-]#N.[Na+].Cl>O>[C:5]([CH:7]1[C:15]2[CH:14]=[CH:13][CH:12]=[C:11]([C:16]([OH:18])=[O:17])[C:10]=2[CH2:9][CH2:8]1)#[N:2]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 6228DimethylformamideHCID 8929Sodium CyanideHCID 12944294HCID 12944294, compound

Product 1

HCID 12944295HCID 12944295, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

In 15 ml. of dimethylformamide is dissolved 1.97 g. of 1-chloroindan-4-carboxylic acid, followed by the addition of 1.47 g. of sodium cyanide. The mixture is stirred for 5 hours, after which 150 ml. of water and 10 ml. of concentrated hydrochloric acid are added. The resultant crystals are collected by filtration and recrystallized from benzene. The described procedure gives 1-cyanoindan-4-carboxylic acid, melting point: 206°-208° C.

Workup

  1. filtrationThe resultant crystals are collected by filtration
  2. customrecrystallized from benzene

Sources & evidence

ORD record
ord-23703f0fd0c54cc68b48b311ab6da569
Source dataset
uspto-grants-1977_02
Patent number
US04007225

Reaction notes

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