Hydrochloric Acid → HCID 20096371, compound

HRID 436185Notes

Reaction equation

HRID 436185 reaction equation
C[O:2][C:3](=[O:23])[CH2:4][C:5]([C:15]1[CH:20]=[CH:19][C:18]([OH:21])=[C:17]([CH3:22])[CH:16]=1)([C:7]1[CH:12]=[CH:11][C:10]([OH:13])=[C:9]([CH3:14])[CH:8]=1)[CH3:6].[OH-].[Na+].Cl>O>[OH:13][C:10]1[CH:11]=[CH:12][C:7]([C:5]([C:15]2[CH:20]=[CH:19][C:18]([OH:21])=[C:17]([CH3:22])[CH:16]=2)([CH3:6])[CH2:4][C:3]([OH:23])=[O:2])=[CH:8][C:9]=1[CH3:14]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 54357386HCID 54357386, compound

Product 1

HCID 20096371HCID 20096371, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A suspension of 314 g of 3,3-bis(4'-hydroxy-3'-methyl-phenyl) butanoic acid methyl ester (m.p. 162° C) and 80 g of sodium hydroxide in 1 liter of water was refluxed for 8 hours while stirring. After cooling to 40° -50° C the suspension was acidified with hydrochloric acid and the 3,3-bis(4'-hydroxy-3'-methylphenyl) butanoic acid was extracted with ether. The ether phase was washed several times with water and then the ether was removed in vacuo. The remaining residue was the white crystallized 3,3-bis(4'-hydroxy-3'-methylphenyl)butanoic acid, m.p. 130° C.

Workup

  1. temperaturewas refluxed for 8 hours
  2. temperatureAfter cooling to 40° -50° C the suspension
  3. extractionthe 3,3-bis(4'-hydroxy-3'-methylphenyl) butanoic acid was extracted with ether
  4. washThe ether phase was washed several times with water
  5. customthe ether was removed in vacuo
  6. customwhite crystallized 3,3-bis(4'-hydroxy-3'-methylphenyl)butanoic acid, m.p. 130° C.

Sources & evidence

ORD record
ord-8c5d2b95417f49f796314e8952717a84
Source dataset
uspto-grants-1977_02
Patent number
US04007282

Reaction notes

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