反应详情

To 150 ml of dimethylformamide 46 ml of phosphorus oxychloride were added dropwise care being taken that the temperature of the reaction mixture did not rise above 20° C. Subsequently to the obtained mixture 103.5 g of 1-methyl-2-phenyl-indole dissolved in 200 ml of dimethylformamide were added dropwise. During the addition the temperature of the reaction mixture was kept in the range of 20° to 40° C and thereupon for 1 hour between 40° and 45° C. Then the reaction mixture was poured into a solution of 490 g of sodium acetate dissolved in 500 ml of water to which 500 g of ice were added. The precipitated aldehyde was separated by suction, washed with water and methanol.

1. customdid not rise above 20° C
2. additionwere added dropwise
3. additionDuring the addition the temperature of the reaction mixture
4. customwas kept in the range of 20° to 40° C
5. additionwere added
6. customThe precipitated aldehyde was separated by suction
7. washwashed with water and methanol