Potassium Hydroxide → HCID 21453014, compound

HRID 436641Notes

Reaction equation

HRID 436641 reaction equation
[Cl:1][CH:2]([F:16])[C:3]([F:15])([F:14])[O:4][C:5]1[CH:13]=[CH:12][C:8]([C:9](Cl)=[O:10])=[CH:7][CH:6]=1.[CH2:17]([NH2:25])[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][NH2:24].[OH-:26].[K+]>C(Cl)CCl>[Cl:1][CH:2]([F:16])[C:3]([F:15])([F:14])[O:4][C:5]1[CH:13]=[CH:12][C:8]([C:9]([NH:24][CH2:23][CH2:22][CH2:21][CH2:20][CH2:19][CH2:18][CH2:17][NH:25][C:9](=[O:10])[C:8]2[CH:7]=[CH:6][C:5]([O:26][C:3]([F:14])([F:15])[CH:2]([F:16])[Cl:1])=[CH:13][CH:12]=2)=[O:10])=[CH:7][CH:6]=1

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 695331,7-HeptanediamineHCID 214528804-(2-Chloro-1,1,2-trifluoroethoxy)benzoyl chloride

Product 1

HCID 21453014HCID 21453014, compound

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

m.p. 153°-154° C., 16.0 g., was prepared as in Example 16 using 4-(2-chloro-1,1,2-trifluoroethoxy)benzoyl chloride (from 23.0 g. of the corresponding acid as in Example 16) in 150 ml. of ethylene dichloride, 5.8 g. of 1,7-heptanediamine, 200 ml. of 10% aqueous potassium hydroxide solution, 500 ml. of ethylene dichloride and recrystallization from acetonitrile using decolorizing charcoal.

Workup

  1. customof ethylene dichloride and recrystallization from acetonitrile using

Sources & evidence

ORD record
ord-10c26637b96e40219c9efffbde17d349
Source dataset
uspto-grants-1977_02
Patent number
US04009208

Reaction notes

Loading…