Cadaverine → HCID 21452954, compound

HRID 436654Notes

Reaction equation

HRID 436654 reaction equation
[F:1][C:2]([F:14])([F:13])[O:3][C:4]1[CH:12]=[CH:11][C:7]([C:8](Cl)=[O:9])=[CH:6][CH:5]=1.[CH2:15]([NH2:21])[CH2:16][CH2:17][CH2:18][CH2:19][NH2:20].[OH-:22].[K+]>C(Cl)CCl>[F:1][C:2]([F:14])([F:13])[O:3][C:4]1[CH:12]=[CH:11][C:7]([C:8]([NH:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][NH:21][C:8](=[O:9])[C:7]2[CH:11]=[CH:12][C:4]([O:22][C:2]([F:1])([F:13])[F:14])=[CH:5][CH:6]=2)=[O:9])=[CH:6][CH:5]=1

Participants

5

Reactant 3

HCID 273CadaverineHCID 14797Potassium HydroxideHCID 1421104-(Trifluoromethoxy)benzoyl Chloride

Product 1

HCID 21452954HCID 21452954, compound

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

m.p. 154°-155° C., 13.8 g., was prepared as in Example 1 using 24.6 g. of 4-trifluoromethoxybenzoyl chloride in 200 ml. of ethylene dichloride, 5.1 g. of 1,5-pentanediamine, 60 ml. of 10% aqueous potassium hydroxide solution, 300 ml. ethylene dichloride and recrystallization from acetonitrile using decolorizing charcoal.

Workup

  1. custom, was prepared as in Example 1 using 24.6 g
  2. customethylene dichloride and recrystallization from acetonitrile using

Sources & evidence

ORD record
ord-1ac22d4ef1444b20a861c302ceeb4e29
Source dataset
uspto-grants-1977_02
Patent number
US04009208

Reaction notes

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