反应详情

Meta-aminopropionanilide, 13.1 g. (0.08 mole) is dissolved in 200 ml. of a 50/50 v/v mixture of glacial acetic acid and saturated sodium acetate solution. To this solution is added 9.2 g. (0.088 moles) of cyclopropane carbonyl chloride. The chloride is added slowly with adequate stirring and cooling. The product, which crystallizes from the solution, is collected by filtration. The product is consecutively washed with a 5 percent solution of sodium hydroxide, a 5 percent solution of hydrochloric acid and water. After washing, the crystals are dried. There is obtained 15 g. (81 percent of theory) of the title compound, m.p. 185°-186° C.

1. dissolution(0.08 mole) is dissolved in 200 ml
2. additionTo this solution is added 9.2 g
3. temperaturecooling
4. customThe product, which crystallizes from the solution
5. filtrationis collected by filtration
6. washThe product is consecutively washed with a 5 percent solution of sodium hydroxide
7. washAfter washing
8. customthe crystals are dried
9. customThere is obtained 15 g