2-Propanone, 1-bromo-3-chloro- → HCID 53993791, compound

HRID 436783Notes

Reaction equation

HRID 436783 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]=[C:10]([NH:12][NH2:13])[CH2:9][N:8]=[C:7]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=3)[C:6]=2[CH:20]=1.[Br:21][CH2:22][C:23](=O)[CH2:24][Cl:25]>O1CCCC1>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]=[C:10]([NH:12][N:13]=[C:23]([CH2:24][Cl:25])[CH2:22][Br:21])[CH2:9][N:8]=[C:7]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=3)[C:6]=2[CH:20]=1

Participants

4

Reactant 2

HCID 1486462-Propanone, 1-bromo-3-chloro-HCID 12612400HCID 12612400, compound

Product 1

HCID 53993791HCID 53993791, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In the manner given in Example 1, 7-bromo-2-hydrazino-5-(2-pyridyl)-3H-1,4-benzodiazepine in tetrahydrofuran can be treated with 1 -bromo-3-chloro-propanone under nitrogen to give 7-bromo-2-[[2-bromo-1-(chloromethyl)ethylidene]hydrazino]-5-(2-pyridyl)-3H-1,4-benzodiazepine.

Sources & evidence

ORD record
ord-6ec41391ad3d48e88f216bd01ceb8c5a
Source dataset
uspto-grants-1977_06
Patent number
US04028356

Reaction notes

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