1-Bromo-3-hydroxypropan-2-one → HCID 86734825, compound

HRID 436791Notes

Reaction equation

HRID 436791 reaction equation
[F:1][C:2]([F:23])([F:22])[C:3]1[CH:4]=[CH:5][C:6]2[N:12]=[C:11]([NH:13][NH2:14])[CH2:10][N:9]=[C:8]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[C:7]=2[CH:21]=1.[Br:24][CH2:25][C:26](=O)[CH2:27][OH:28]>O1CCCC1>[F:23][C:2]([F:1])([F:22])[C:3]1[CH:4]=[CH:5][C:6]2[N:12]=[C:11]([NH:13][N:14]=[C:26]([CH2:27][OH:28])[CH2:25][Br:24])[CH2:10][N:9]=[C:8]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[C:7]=2[CH:21]=1

Participants

4

Reactant 2

HCID 117448281-Bromo-3-hydroxypropan-2-oneHCID 22768402HCID 22768402, compound

Product 1

HCID 86734825HCID 86734825, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In the manner given in Example 1, 7-(trifluoromethyl)-2-hydrazino-5-phenyl-3H-1,4-benzodiazepine in tetrahydrofuran can be treated with 1-bromo-3-hydroxypropanone under nitrogen to give 7-(trifluoromethyl)-2-[[2-bromo-1-(hydroxymethyl)ethylidene]hydrazino]-5-phenyl-3H-1,4-benzodiazepine.

Sources & evidence

ORD record
ord-aa17a94ab9874fe397cac37c4b4bad7f
Source dataset
uspto-grants-1977_06
Patent number
US04028356

Reaction notes

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